If you’ve tried antidepressants without meaningful relief, Spravato® (esketamine) offers a different, evidence-based approach. This FDA-approved treatment for treatment-resistant depression works differently than traditional antidepressants and may help relieve symptoms more rapidly.
At Zephyr Behavioral Health & Wellness, Spravato is administered in a calm, supportive clinical setting with close monitoring from our team.
What is Spravato (Esketamine)?
Spravato is a prescription nasal spray derived from ketamine that works on the brain’s glutamate system, helping restore neural connections involved in mood, clarity, and resilience.
Unlike traditional antidepressants, which may take weeks to work, Spravato may begin improving symptoms more quickly for some individuals.
Spravato is FDA-approved for:
- Treatment-resistant depression
- Depression with suicidal thoughts or behaviors
Many people consider Spravato when:
- Antidepressants have not provided enough relief
- Symptoms continue despite ongoing treatment
- They are looking for an evidence-based alternative treatment
What to Expect During Spravato Treatment
During your appointment:
Spravato is administered in our clinic under the supervision of trained medical providers.
During treatment:
- You’ll self-administer the nasal spray in clinic
- Appointments typically last about two hours
- You’ll relax in a private, comfortable treatment space
- Our clinical team will monitor you throughout your visit
Treatment timeline:
- Weeks 1–4: Twice weekly
- Maintenance: Weekly, then every other week depending on your response
Some clients experience temporary side effects such as:
- Mild dissociation or a “floaty” feeling
- Dizziness
- Nausea
- Temporary increase in blood pressure
These effects are short-lived and monitored throughout your treatment.
After Your Appointment
After treatment, our team will make sure you feel safe and supported before heading home. You’ll need to plan for a ride home after your appointment as Spravato can temporarily affect alertness and coordination. Most side effects resolve the same day.
Why Choose Zephyr Behavioral Health & Wellness for Spravato Treatment?
Starting a new treatment for depression can feel like a big step. Our goal is to make the process feel supportive and personalized from the very beginning.
At Zephyr, Spravato treatment includes:
- Care from psychiatric providers experienced in treating complex depression
- A calm and comfortable environment designed to help you feel at ease during treatment
- Ongoing monitoring and support throughout every appointment
- Treatment plans tailored to your symptoms, goals, and history
- Access to additional services, including therapy, medication management, and TMS when appropriate
We understand that many people seeking Spravato have already tried multiple treatments without enough relief. Our team will take the time to listen, answer questions, and help you explore the treatment options that make the most sense for you.
Cost & Insurance Information
Spravato is often covered by insurance for eligible clients. Our team can help with:
- Benefits verification
- Prior authorizations
- Insurance questions
- Financial assistance programs when available
Frequently Asked Questions About Spravato
How quickly does Spravato work?
Some clients notice improvement within the first few treatments, sometimes within days.
Will I feel “high” during treatment?
You may feel mildly dissociated or “floaty,” which is expected and closely monitored by our team.
Can I drive after treatment?
No, you’ll need a ride home and can resume driving the next day.
Is Spravato the same as ketamine therapy?
Spravato is related to ketamine therapy, but they are not exactly the same treatment. Spravato is an FDA-approved nasal spray form of esketamine administered in a controlled clinical setting.
Will insurance cover this?
Many plans do. We handle verification and prior authorizations for you.
What if nothing else has worked?
Spravato was specifically developed for people with treatment-resistant depression and may offer another option when traditional antidepressants have not helped enough.
Take the First Step Toward Healing
If you’re struggling with depression and have not found relief through traditional treatments, Spravato at Zephyr Behavioral Health & Wellness could be the solution.
Contact us today to schedule a consultation to see if Spravato is right for you.
